夜间饮食频率与甲状腺功能和敏感性之间的关联:来自NHANES数据库的横截面研究
Yanhao Zhang1, Songbai Zhou1, Shiguang Liu1
1Department of Clinical Laboratory, Xichang People's Hospital, Xichang, China.
Frontiers in endocrinology
|January 7, 2025
概括
夜间吃饭的频率与甲状腺激素变化有关,如甲状腺蛋白 (Tg) 和三甲状腺素 (T3),但不是甲状腺敏感性. 需要进一步的研究来证实这些关于甲状腺功能的发现.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 时间生物学 时间生物学
背景情况:
- 甲状腺功能受到昼夜节律的影响.
- 夜间饮食频率对甲状腺功能和敏感性的影响尚不清楚.
研究的目的:
- 调查夜间饮食频率与甲状腺功能和敏感性之间的关联.
- 分析夜间饮食对甲状腺激素指数和敏感性标记物的影响.
主要方法:
- 利用了美国国家健康和营养检查调查 (2007-2012) 的6093名参与者的数据.
- 通过24小时的饮食回忆 (晚上10点至凌晨4点之间摄入食物) 评估夜间饮食频率.
- 分析了甲状腺激素 (T3,T4,FT3,FT4,TSH,Tg,TPOAb) 和灵敏度指数 (FT3/FT4,TSHI,TT4RI,TFQI),使用权重回归分析,包括子组和相互作用测试.
主要成果:
- 较高的夜间饮食频率与提升的甲状腺蛋白 (Tg) 水平 (OR 1.223) 和降低的三甲状腺素 (T3) 和甲状腺过氧化酶抗体 (TPOAb) 水平有关.
- 在糖尿病患者中,Tg与夜间饮食之间的关联更为强烈.
- 在没有DM的个体中,TPOAb和夜间饮食之间的联系更为强烈.
- 根据夜间饮食频率,没有观察到甲状腺激素敏感性的显著差异.
- 观察到的激素波动保持在正常临床范围内.
结论:
- 夜间饮食频率与特定的甲状腺功能标志物有显著的关联.
- 甲状腺激素敏感性似乎不会受到夜间饮食频率的显著影响.
- 虽然已注意到相关性,但需要进一步的研究来确定夜间饮食和甲状腺功能之间的因果关系.
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