水果和蔬菜消费和炎症性肠病:一个病例对照研究
Anas M Almofarreh1, Haytham A Sheerah2, Ahmed Arafa3,4
1Assistant Deputyship for Health Investment Development, Ministry of Health, Riyadh 11451, Saudi Arabia.
Life (Basel, Switzerland)
|January 8, 2025
概括
每日蔬菜摄入量可能会降低女性的克罗恩病 (CD) 风险,但不能降低男性的风险,这表明性别特定的饮食对炎症性肠道疾病 (IBD) 的影响. 对这些IBD性别差异的进一步研究是有必要的.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是具有复杂原因的慢性疾病.
- 饮食因素被怀疑是IBD发展的贡献者.
- 本研究研究了水果和蔬菜摄入量与IBD风险之间的联系,考虑到性别差异.
研究的目的:
- 调查日常水果和蔬菜消费与患性结肠炎 (UC) 和克罗恩病 (CD) 的风险之间的关联.
- 探索饮食与IBD风险之间的关系中的潜在的性别特异性差异.
主要方法:
- 在沙特阿拉伯的利雅得进行了一项基于医院的病例控制研究.
- 从158名UC患者,245名CD患者和395名对照患者收集了数据,这些患者使用了自我管理的问卷.
- 基于水果和蔬菜的消费,用于计算IBD风险的几率比率 (ORs) 和95%置信区间 (95%CI) 的物流回归分析.
主要成果:
- 每日蔬菜消费与女性克罗恩病 (CD) 风险有显著的反向关联 (OR:0.41,95% CI:0.20-0.84).
- 在女性中,蔬菜消费与性结肠炎 (UC) 之间没有发现显著的关联,在男性中也没有发现UC或CD.
- 无论是男性还是女性,水果消费与UC或CD风险无关.
结论:
- 每日蔬菜摄入量与克罗恩病 (CD) 的风险降低有关,特别是在女性中.
- 这些发现表明,性别特异性饮食对发展炎症性肠病 (IBD) 风险的潜在影响.
- 需要进一步的研究来阐明IBD病因学中这些性别差异背后的机制.
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