小型GTPase MRAS是一个破碎的开关

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Updated: Jun 2, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

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Gabriela Bernal Astrain1,2, Regina Strakhova1,2, Chang Hwa Jo1

  • 1Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, H3T 1J4, Canada.

Nature communications
|January 14, 2025
PubMed
概括

MRAS GTPase 不能作为一个分子开关,即使在激活突变的情况下也保持GDP负载. 这挑战了RAS GTPases的传统模型,并建议重新解释之前的MRAS研究.

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