肠道微生物组成和痴呆症之间的相互作用.
Rad Ghannadzadeh Kermani Pour1, Sara Kamali Zounouzi1, Melina Farshbafnadi1,2
1School of Medicine, 48439 Tehran University of Medical Sciences , Tehran, 1416634793, Iran.
Reviews in the neurosciences
|January 20, 2025
概括
肠道微生物组影响痴呆症. 通过饮食或益生菌改变肠道细菌可能提供安全,有效的辅助疗法,以改善认知功能并减缓痴呆症的进展.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 新兴研究将肠道微生物群组成与神经心理障碍 (包括痴呆症) 联系起来.
- 痴呆症带来了重大的社会经济负担,肠道微生物组是其发展的潜在因素.
- 肠道微生物产生的短链脂肪酸和神经递质等细菌代谢物可能会影响痴呆症的发病率和进展.
研究的目的:
- 探索肠道微生物群在痴呆症发病过程中的作用.
- 为了确定与痴呆有关的特定细菌物种和代谢物.
- 评估肠道微生物群调制作为痴呆症潜在的治疗策略.
主要方法:
- 审查关于肠道微生物群和痴呆症的当前研究.
- 识别与痴呆相关的细菌物种 (例如, *Bifidobacterium breve*, *Akkermansia muciniphila*).
- 与痴呆症相关的细菌代谢物 (例如短链脂肪酸,脂多糖) 的分析.
主要成果:
- 特定的肠道细菌及其代谢物与痴呆症的发病有关.
- 通过饮食或益生菌来调节肠道微生物群,在预防或减缓痴呆症方面表现有前途.
- 向微生物代谢物可以作为痴呆症的辅助疗法.
结论:
- 肠道微生物群是新型痴呆症治疗的有希望的目标.
- 饮食干预和益生菌可以调节肠道微生物群,潜在地改善认知功能.
- 针对微生物组的治疗方法提供了一种安全有效的方法,以补充传统的痴呆症治疗方法.
相关概念视频
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
Bacterial Flora of the Large Intestine
376
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
376
Dementia
93
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
93
Irritable Bowel Syndrome I: Introduction
243
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
243
Alzheimer's Disease: Overview
439
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
439


