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Updated: Jul 29, 2026

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

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单个细胞的基于滴滴的高通量3D基因组结构映射与同时转录组学

Honggui Wu1,2,3, Maoxu Wang1,2, Yinghui Zheng1,2

  • 1Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University, Beijing, China.

Cell discovery
|January 21, 2025
PubMed
概括

高通量单细胞Hi-C (dscHi-C) 揭示了老鼠大脑衰老期间的3D基因组变化. 这些结构变化影响神经元和质细胞功能,为大脑发育和疾病提供了洞察力.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...