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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
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在微重力模拟过程中,多能介质干细胞的转录基因变化发生了转录基因变化.

D A Yakubets1, L B Buravkova2

  • 1Institute of Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia. lizard_96@mail.ru.

Doklady. Biochemistry and biophysics
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PubMed
概括
此摘要是机器生成的。

太空飞行导致骨质损失 (骨质疏松症) 通过减少介质干细胞 (MSCs) 的增殖. 模拟的微重力显著降低了对细胞分裂至关重要的基因的调节,影响了骨的补充.

关键词:
有关RNA测序的RNA测序基因表达的基因表达方式多能介质干细胞 (MMSCs) 是一种多能介质干细胞.它们的扩散和扩散.在模拟的微重力环境中进行模拟.

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科学领域:

  • 太空生物学空间生物学
  • 细胞生物学 细胞生物学
  • 生物医学研究的研究.

背景情况:

  • 太空飞行对人类生理构成风险,特别是骨质损失 (骨质疏松症).
  • 了解骨组织补充的细胞机制对于长期太空任务至关重要.
  • 介质细胞干细胞 (MSCs) 在骨再生中发挥着关键作用.

研究的目的:

  • 研究模拟微重力对人类骨髓介质干细胞 (hBM-MSCs) 转录组特征的影响.
  • 为了确定基底细胞变化的分子机制,以应对太空飞行条件.

主要方法:

  • 用RNA测序分析了hBM-MSCs在5天模拟微重力后的基因表达变化.
  • 光显微镜被用来验证细胞水平的转录发现.

主要成果:

  • 模拟的微重力导致细胞增殖和细胞周期的线性阶段所涉及的基因的显著下调.
  • 转录性变化表明hBM-MSCs的增殖活性下降.

结论:

  • 模拟的微重力降低了hBM-MSCs的繁殖能力.
  • 这些发现突出了在宇航员中观察到的骨质疏松症的潜在细胞机制.
  • 需要进一步的研究来开发对太空飞行引起的骨损失的对策.