Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Identification of Risk Loci for Radiotherapy-Induced Tinnitus and Hearing Loss Through Integrated Genomic Analysis.

International journal of molecular sciences·2025

Same author

Effectiveness of Mindfulness-Based Stress Reduction on Mental Health and Psychological Quality of Life among University Students: A GRADE-Assessed Systematic Review.

Evidence-based complementary and alternative medicine : eCAM·2024

Same author

The complementary contribution of each order topology into the synchronization of multi-order networks.

Chaos (Woodbury, N.Y.)·2023

Same author

Stability and Bautin bifurcation of four-wheel-steering vehicle system with driver steering control.

Chaos (Woodbury, N.Y.)·2023

Same author

Minimum taxi fleet algorithm considering human spatiotemporal behaviors.

Chaos (Woodbury, N.Y.)·2023

Same author

Birth of strange nonchaotic attractors in a piecewise linear oscillator.

Chaos (Woodbury, N.Y.)·2022

Search research articles

相关实验视频

Updated: May 31, 2025

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

转录组证据揭示了ASD中突触可塑性控制的功能障碍机制.

Chao Kong¹, Zhitong Bing², Lei Yang²

¹School of Systems Science, Beijing Normal University, Beijing 100875, China.

|January 25, 2025

概括

这项研究通过分析突触可塑性网络,揭示了自闭症谱系障碍 (ASD) 失调的翻译控制. 新的算法识别了关键的分子参与者和细胞特异性模式,为ASD提供了潜在的诊断生物标志物.

关键词:

在ASD中,使用的是ASD.一个因果关系网络.逻辑模型逻辑模型逻辑模型信号传输网络的信号传输网络.单细胞序列的一个单细胞序列.突触的可塑性突触的可塑性转录组 (transcriptome) 是一个转录组.

更多相关视频

Strategies for Assessing Autistic-Like Behaviors in Mice

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

相关实验视频

Last Updated: May 31, 2025

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

Strategies for Assessing Autistic-Like Behaviors in Mice

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

科学领域:

神经科学是一个神经科学.
系统生物学系统生物学
计算生物学计算生物学

背景情况:

自闭症谱系障碍 (ASD) 具有突触可塑性功能障碍的特征,但潜在的分子机制尚未完全理解.
调查谷氨酸性神经元中的突触后信号传导对于理解ASD病理生理学至关重要.

研究的目的:

揭示自闭症谱系障碍 (ASD) 中翻译控制的故障,使用来自前额叶皮层 (PFC) 的单细胞核转录学数据.
分析后突触信号传导网络,并确定ASD中失调的分子机制.

主要方法:

开发了一个管道,将信号传导网络转换为mRNA信号调节网络 (mSiReN),用于RNA级分析.
通过整数值编程和因果推理 (CS-NIVaCaR) 采用细胞特异性网络推理和mRNA调节网络的细胞特异性概率上下文化 (CS-ProComReN) 来识别不同细胞类型的核心模块和激活的子路径.

主要成果:

鉴定了参与蛋白质翻译的失调关键分子 (EIF4EBP1,EIF4E),对于长期强化 (LTP) 和长期抑郁 (LTD) 至关重要,尽管缺乏差异表达.
在激发性和抑制性神经元中发现了EIF4EBP1-EIF4E模块的独特,因果相关的激活模式.

结论:

引入了一种新的方法 (mSiReN) 来分析转录组学数据以解析信号传导网络并将其映射到蛋白质水平.
突出了在ASD中已识别的融合失调路径中的潜在诊断和预后生物标志物.
提出算法作为系统生物学研究的强大工具,用于分析omics和监管网络.