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Updated: May 29, 2025

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D-2-基酸盐通过表观遗传重编程损害了DNA修复.

Fengchao Lang1, Karambir Kaur1, Haiqing Fu2

  • 1Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Nature communications
|February 7, 2025
PubMed
概括

癌细胞中的异酸脱酶 (IDH) 突变通过改变色素结构来破坏DNA修复. 代代谢物D-2-基酸盐 (D-2-HG) 损害了DNA修复蛋白的招募,影响了IDH突变恶性瘤中的基因组稳定性.

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