Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Microstructured chitosan mesh scaffold for efficient production of cell-cultured meat.

Scientific reports·2026
Same author

A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.

Advanced healthcare materials·2025
Same author

Development of a sensor-compatible vascular microphysiological system for metabolic monitoring during drug-induced endothelial injury.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2025
Same author

EMT-Induced Morphological Variations on Living Cell Membrane Surface.

Analytical chemistry·2025
Same author

Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta.

Lab on a chip·2024
Same author

Editorial: Modelling and sensing platform for cancer and tumour microenvironment.

Frontiers in bioengineering and biotechnology·2024

相关实验视频

Updated: May 24, 2025

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

1.5K

[使用微生理系统的瘤微环境中的药物和细胞动态]

Yuji Nashimoto1

  • 1Laboratory for Bioengineering and Biomaterials, Institute of Science Tokyo.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
|March 2, 2025
PubMed
概括

微生理系统 (MPS) 通过血管网络模拟瘤微环境 (TME). 这种方法增强了对癌细胞和周围细胞相互作用的理解,这对于癌症进展研究至关重要.

科学领域:

  • 在瘤学瘤学.
  • 生物技术是生物技术.
  • 细胞生物学 细胞生物学

背景情况:

  • 瘤微环境 (TME) 包括像免疫细胞和纤维细胞这样的非癌细胞,以前认为它们是被动的.
  • 新出现的证据强调了这些TME成分及其分泌物在推动癌症进展中的关键作用.
  • 了解TME内部的复杂相互作用对于开发有效的癌症疗法至关重要.

研究的目的:

  • 审查包括血管网络的癌症微生理系统 (MPS) 的最新进展.
  • 使用这些先进的模型,阐明瘤微环境中的细胞和分子动力学.
  • 突出MPS在准确评估TME复杂性和功能方面的实用性.

主要方法:

  • 审查最近的科学文献,重点关注癌症微生理系统 (MPS).
  • 对将血管网络纳入瘤MPS平台的研究进行分析.
  • 检查这些工程TME模型中的详细细胞和分子动力学的研究.

主要成果:

  • 集成血管网络的微生理系统 (MPS) 为研究TME提供了一个复杂的平台.
  • 这些系统使得控制操作和详细分析癌细胞和树皮组成部分之间的相互作用.
  • 血管化的瘤MPS促进了TME内的生理条件和细胞反应的更准确的建模.

更多相关视频

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

11.5K
Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.3K

相关实验视频

Last Updated: May 24, 2025

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

1.5K
Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

11.5K
Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.3K

结论:

  • 结合血管网络的癌症MPS代表了TME研究的重大进步.
  • 这些模型为控制癌症进展的动态细胞和分子机制提供了前所未有的洞察力.
  • 进一步开发和应用血管化的MPS对于未来的癌症研究和治疗策略至关重要.