Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: May 24, 2025

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

11.7K

使用微制造的喷嘴阵列生产高吞吐量微粒.

Süleyman Çelik1,2, Ümit Çelik3, Ali Koşar2,4,5,6

  • 1Department of Molecular Biology and Genetics, Istanbul Technical University 34469 Istanbul Turkey.

RSC advances
|March 4, 2025
PubMed
概括
此摘要是机器生成的。

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ultrasensitive quantification of Hg<sup>2+</sup> in real samples using colorimetric, fluorimetric and smartphone-based triple-mode system integrated with a new indoline-fused chromenylium-cyanine chemodosimeter.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Processing-defined organization governs plasmonic response and stability in lipid-coated gold nanoparticles.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Reply to comment on '3D melt electrowritten MXene-reinforced scaffolds for tissue engineering applications'.

Biofabrication·2026
Same author

Biointerfacial mechanical responses of supported lipid membranes to Gramicidin D revealed by QCM-D.

Colloids and surfaces. B, Biointerfaces·2026
Same author

PEI-Treated Eggshell and Onion Membranes as Natural Supports for Urease Immobilization: A Performance and Stability Evaluation.

ACS omega·2025
Same author

Spatial Designs on Metamaterial Sensors for Enhancing Signals and Detecting Extracellular Vesicles.

ACS applied materials & interfaces·2025
Same journal

High-turnover copper-catalyzed amination of aryl bromides: exploring catalyst and ligand degradation pathways.

RSC advances·2026
Same journal

Sb-based metal oxide and sulfide anode materials for alkali-ion batteries.

RSC advances·2026
Same journal

Directed evolution of a cytochrome P450 monooxygenase for improved perillyl alcohol biosynthesis <i>via</i> a tailored genetically encoded biosensor.

RSC advances·2026
Same journal

Superspin-glass dynamics and magnetic memory in ZnFe<sub>2</sub>O<sub>4</sub> nanoparticles synthesized <i>via</i> a green egg-white-assisted route.

RSC advances·2026
Same journal

Porous and luminescent Dy-doped Co-BTC MOFs for label-free detection of tetracycline and vanadium traces in water.

RSC advances·2026
Same journal

An optimized green simultaneous HPLC analysis of dissolution rate monitoring for valsartan and sacubitril in tablet medications.

RSC advances·2026
查看所有相关文章

一个新的微粒生产系统 (MPS) 能够高效,高吞吐量制造统一的Poly (d,l-lactide-co-glycolide) (PLGA) 微粒,用于控制药物输送. 该系统显示了可扩展生产先进治疗技术的潜力.

科学领域:

  • 生物材料工程 生物材料工程
  • 药物输送系统 药物输送系统
  • 纳米技术 纳米技术

背景情况:

  • 聚合物微粒对于先进的药物输送至关重要,增强治疗疗效和减少副作用.
  • 微粒制造的传统方法往往受到尺寸变化,药物降解和低生产效率等问题的困扰.

研究的目的:

  • 开发一个微粒子生产系统 (MPS),集成精密喷雾技术与压电传感器,用于高通量微粒制造.
  • 描述由MPS生产的Poly (d,l-lactide-co-glycolide) (PLGA) 微粒的尺寸,形态和药物封装/加载效率.
  • 评估含有 (CHL) 的PLGA微粒的药物释放特征和抗菌疗效.

主要方法:

  • 开发了一种MPS,将精密喷雾与基于微型喷嘴阵列的压电传感器相结合.
  • 在二甲 (DCM) 和二甲基碳酸盐 (DMC) 中溶解的利用的聚甲 (d,l-lactide-co-glycolide) (PLGA) 用于微粒子合成.
  • 使用扫描电子显微镜 (SEM) 和聚焦离子束 (FIB) 分析来表征微粒.
  • 评估了 (CHL) 封装和加载效率,并进行了体外药物释放研究.
  • 对大肠杆菌 (大肠杆菌) 的评估抗菌活性.

主要成果:

  • 实现了具有优异尺寸均性 (平均直径8.9±1.7μm) 的PLGA微粒的高通量生产.

更多相关视频

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.0K
A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

10.2K

相关实验视频

Last Updated: May 24, 2025

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

11.7K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.0K
A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

10.2K
  • SEM和FIB分析揭示了不同的微粒子结构,受溶剂波动的影响.
  • 获得了38.7%的烯 (CHL) 封装效率和16.2%的加载效率.
  • 已证明持续的CHL释放和有效的抗菌活性对抗大肠杆菌.

    • 结论:

    • 开发的MPS提供了一种可扩展和高效的方法来生产统一的PLGA微粒.
    • 该系统有助于控制药物释放配置文件,这对于先进的治疗应用至关重要.
    • 这项技术在工业规模生产药物输送系统方面具有重大潜力.