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相关概念视频

Immunological Memory01:23

Immunological Memory

514
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
514
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

762
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
762
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

622
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
622
Vaccinations01:51

Vaccinations

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Overview
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

707
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
707

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相关实验视频

Updated: May 23, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

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一种可变的深度学习方法来建模记忆T细胞动态.

Christiaan H van Dorp1, Joshua I Gray2, Daniel H Paik2

  • 1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York City, USA.

bioRxiv : the preprint server for biology
|March 10, 2025
PubMed
概括
此摘要是机器生成的。

这项研究揭示了流感感染后免疫记忆形成期间肺T细胞动态的多样性. 一种新的深度学习方法分析高维单细胞数据,以发现T细胞异质性和长期持久性.

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A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
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Murine Superficial Lymph Node Surgery
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Murine Superficial Lymph Node Surgery

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Last Updated: May 23, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

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A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
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A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice

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Murine Superficial Lymph Node Surgery
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 系统生物学 系统生物学

背景情况:

  • 机械模型传统上使用有限的标记物简化免疫细胞种群.
  • 高维单细胞数据对现有的建模方法提出了挑战.
  • 了解组织内存T细胞 (TRM) 动态对于有效的免疫是至关重要的.

研究的目的:

  • 开发一种新的计算方法来分析免疫反应中的高维单细胞数据.
  • 在流感感染解脱过程中调查肺 CD4 和 CD8 TRM细胞的动态和异质性.
  • 为解释复杂,时间序列,高维度的生物数据提供一个框架.

主要方法:

  • 开发了一个深度学习框架,整合了随机变化推理.
  • 在单细胞流细胞计数据上直接训练模型,同时推断出人口结构和模型参数.
  • 在小鼠流感感染模型中应用该方法来研究肺TRM的发展和持久性.

主要成果:

  • 在免疫反应解决过程中,在肺 CD4 和 CD8 TRM 种群中发现了显著的表型多样性.
  • 在TRM子集中展示了不同的,依赖时间的动态.
  • 揭示了长期的TRM异质性是通过与持久的BCL-2hi子集的差异化来维持的.

结论:

  • 这项研究为组织局部免疫记忆的复杂动态提供了新的见解.
  • 开发的计算方法为解释高维,时间序列生物数据提供了一个强大的新基础.
  • 这种方法广泛适用于各种生物系统,需要分析复杂的细胞动态.