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相关概念视频

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Chronic Imaging of Mouse Visual Cortex Using a Thinned-skull Preparation
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在非人类灵长类动物中,通过Smart Dura进行多式光学成像和调制.

Nari Hong1,2, Sergio Montalvo Vargo3, Gaku Hatanaka2,4

  • 1Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

bioRxiv : the preprint server for biology
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PubMed
概括
此摘要是机器生成的。

我们开发了Smart Dura,这是一种用于非人类灵长类动物 (NHPs) 的大规模神经接口,可实现多模式大脑记录和操纵. 这项技术为人类应用推进了翻译神经技术.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 翻译神经技术 翻译神经技术

背景情况:

  • 多模式神经接口为记录和操纵神经活动提供了增强的时空分辨率.
  • 目前的技术往往局限于小型动物模型,阻碍转化到更大的大脑,如非人类灵长类动物 (NHPs).

研究的目的:

  • 为了在NHP中展示新开发的大规模神经接口Smart Dura的多式联络应用.
  • 展示Smart Dura在整合各种光学和电生理学技术以进行全面的大脑研究方面的能力.

主要方法:

  • 开发了Smart Dura,这是NHP的大型神经接口,提供电生理学记录和光学可访问性.
  • 结合智能Dura与多光子显微镜 (二光子和三光子),光学相干断层扫描血管造影 (OCTA) 和内在信号光学成像 (ISOI).
  • 使用Smart Dura进行光学操纵,包括光血栓性损伤和光遗传学.

主要成果:

  • 通过透明的Smart Dura实现了高达550微米深度的光成像.
  • 启用与OCTA和ISOI同时进行电生理学,以评估血管和神经动态.
  • 在20毫米直径的区域内证明了缺血性中风和光遗传神经调节的诱导.

结论:

  • 智能Dura促进了对NHPs的大脑动态的全面调查.
  • 这种多模式接口显著地推动了转化神经技术向人类应用.