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相关概念视频

Olfaction01:25

Olfaction

50.0K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
14.6K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

14.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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相关实验视频

Updated: Apr 12, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
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The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

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时间很重要:从嗅觉球中的围产期神经发生学到的经验教训

Teresa Liberia1, Kimberly Han1, Natalie J Spence1

  • 1Department of Neuroscience and Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.

The Journal of comparative neurology
|March 24, 2025
PubMed
概括

嗅球 (OB) 中颗粒细胞 (GC) 神经发生的时间决定了它们的最终位置和突触连接. 这种发育时间影响着预测神经元如何处理气味信息.

关键词:
颗粒细胞是颗粒细胞.内部神经元内部神经元当地电路的局部电路.神经发生神经发生.嗅觉灯泡是一种嗅觉灯泡.突触形成的突触形成

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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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科学领域:

  • 神经科学是一个神经科学.
  • 嗅觉系统研究研究 嗅觉系统研究
  • 发育神经生物学的发展神经生物学

背景情况:

  • 气味信息处理依赖于嗅球 (OB) 中复杂的神经回路.
  • 在OB中微调气味编码的局部突触电路,涉及抑制颗粒细胞 (GCs).
  • 了解与投射神经元树突相对的GC组织对于破译嗅觉处理至关重要.

研究的目的:

  • 研究嗅球 (OB) 中颗粒细胞 (GCs) 的发育时间表.
  • 确定GCs的层状分布和突触生成模式.
  • 阐明GC神经发生的时间如何影响它们与投影神经元的集成.

主要方法:

  • 详细调查颗粒细胞 (GC) 神经发生时间.
  • 从胚胎形成到成年期的GC层状分布的分析.
  • 检查GC和投射神经元树突之间的协同生成.

主要成果:

  • 颗粒细胞 (GCs) 呈现出一个连续的发育模式,与外部-内部成熟.
  • 生后一周出生的GC显示了特定的亚层分布,表明了发育过渡.
  • 互交的突触电路集成发生在神经发生后大约10天.

结论:

  • 神经发生的时间是GC解剖结构在OB的一个关键决定因素.
  • GC的定位会影响它们的偏好突触连接与中枢细胞或状细胞树突.
  • 这项研究提供了对嗅觉信息处理的发展基础的见解.