Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Friendships and Close Friendships01:20

Friendships and Close Friendships

Friendship formation is a dynamic process shaped by psychological, cultural, and social factors. Friendships play a crucial role in emotional well-being, social development, and personal identity from childhood to adulthood.Childhood and Early FriendshipsFriendships in childhood often arise due to shared environments, such as school or neighborhood interactions. At this stage, proximity and common interests serve as the primary basis for connection. As children grow, their friendships evolve...
Companionate Love01:27

Companionate Love

Companionate love is a fundamental aspect of long-term relationships, characterized by deep affection, mutual respect, and emotional intimacy. Unlike passionate love, which is driven by intense emotions and physical attraction but often declines over time, companionate love remains stable and can even strengthen with shared experiences and commitment. Psychological and biological mechanisms underpin this enduring form of love, influencing relationship longevity and satisfaction.Stability and...
Jealousy in Romantic Relationships01:23

Jealousy in Romantic Relationships

Jealousy is an instinctive yet socially complex emotion that arises when a close relationship is threatened. Its origins lie in both biological imperatives and sociocultural conditioning, making it a multifaceted psychological construct. Although universally experienced, the triggers and expressions of jealousy vary notably between individuals, especially across genders, due to evolutionary pressures and cultural influences.Gender Differences and Evolutionary TheoryEvolutionary theory explains...
Microbe-Plant Interactions01:09

Microbe-Plant Interactions

Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pharmacological Stratification of Public Bioactivity Databases: A Reusable, OECD-Anchored Curation and Benchmarking Framework Demonstrated for Opioid Receptors.

bioRxiv : the preprint server for biology·2026
Same author

Contact-Network Phenotyping of the CDK Family Reveals Selective Distal C-Lobe Contact Redistribution by Modern CDK5 Inhibitors and a Quantitative Selectivity Landscape against CDK2 and CDK1.

Journal of chemical information and modeling·2026
Same author

Rescuing the Function of Missense-Mutated Tumor Suppressor <i>VHL</i> using Stabilizing Small Molecules.

bioRxiv : the preprint server for biology·2026
Same author

Correction to "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties".

ACS medicinal chemistry letters·2026
Same author

Defining the Data set Defines the QSAR Claim.

Journal of chemical information and modeling·2026
Same author

Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.

ACS medicinal chemistry letters·2026

相关实验视频

Updated: May 31, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

16.9K

消毒和成:朋友还是敌人?

Wayne Childers1, Khaled Elokely2, Magid Abou-Gharbia1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.

Pharmaceuticals (Basel, Switzerland)
|March 27, 2025
PubMed
概括

德佐辛提供有效的止痛药,副作用和成潜力比吗啡更少. 研究探索其用于慢性疼痛和阿片类药物成治疗的用途.

科学领域:

  • 药理学 药理学 是一个学科.
  • 神经科学是一个神经科学.
  • 疼痛管理 疼痛管理

背景情况:

  • 片的神经效应已知数千年.
  • 吗啡于1803年分离出来,成为广泛使用的止痛药,但具有成风险.
  • 德佐辛 (Dalgan®) 是作为一种更安全的替代品而开发的,于1986年上市,并于2011年在美国停止生产.

研究的目的:

  • 审查支持德佐辛非成性特征的数据.
  • 探索dezocine在治疗阿片类药物成和戒断方面的潜力.
  • 讨论慢性用药的新配方.

主要方法:

  • 审查关于dezocine的现有药理数据.
  • 对关于副作用和依赖性的临床观察结果的分析.
  • 检查了对血清素和北上腺素载体抑制的研究.
  • 评估最近关于成管理应用的研究.

主要成果:

  • 德佐辛证明有效的止痛药与有限的阿片类药物相关的副作用.
  • 它显示很少或没有报告的依赖和成的潜力.
  • 它对血清素和上腺素载体的作用表明它在神经病痛中具有实用性.
关键词:
抑制NRI再吸收的抑制方法管理成 管理成德佐辛 (dezocine) 是一种葡萄糖.有部分G蛋白偏差的MOR激动剂.

更多相关视频

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
04:11

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

16.8K

相关实验视频

Last Updated: May 31, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

16.9K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
04:11

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

16.8K
  • 新出现的数据显示了成管理的潜力.
  • 结论:

    • 德佐辛是一种有前途的止痛药,具有良好的安全性.
    • 它独特的药理要求进一步研究慢性疼痛和成治疗.
    • 新配方正在开发中,以支持持续的治疗用途.