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Updated: Feb 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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有效的,选择性的PDE11A4抑制剂,具有改善的药物特性

Shams Ul Mahmood1, Rama Krishna Boddu1, Jeremy Eberhard2

  • 1Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.

ACS medicinal chemistry letters
|February 18, 2026
PubMed
概括

研究人员优化了pyrrolopyrimidine化合物,以创建一个强大的基化酶11A4 (PDE11A4) 抑制剂. 这种新的抑制剂显示出改善的药物特性和有前途的基于细胞的活性,用于未来的研究.

关键词:
这是LLPS活动.在 PDE11A4A4 中,基于细胞的细胞活动.药物的药物特性.这是一种固酶抑制剂.

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