Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

2.6K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.6K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.0K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.0K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.3K
Cell Migration01:19

Cell Migration

4.7K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Rigidity Sensing of Inclusions Directs Differentiated Cell Elongation and Force Generation across Phenotypes.

ACS biomaterials science & engineering·2025
Same author

Optimizing gelation time for cell shape control through active learning.

Soft matter·2025
Same author

Disodium Cromoglycate Templates Anisotropic Short-Chain PEG Hydrogels.

ACS applied materials & interfaces·2024
Same author

Coacervate or precipitate? Formation of non-equilibrium microstructures in coacervate emulsions.

Soft matter·2023
Same author

Topological defect-propelled swimming of nematic colloids.

Science advances·2022
Same author

Microstructure of continuous shear thickening colloidal suspensions determined by rheo-VSANS and rheo-USANS.

Soft matter·2022
Same journal

Bioinspired Electrostatic-Field Perturbated Sensing for General Material Noncontact Perception.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Engineering Layered Magnetic Hydrogels for Cell Placement via Shear and Magnetic Field-Induced Assembly.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Interfacial Acid Sites-Mediated ZnO-Based Electrocatalysts for Sustainable Dual-Pathway H<sub>2</sub>O<sub>2</sub> Production and Rechargeable Zn-H<sub>2</sub>O<sub>2</sub> Electrochemical Cell.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Toward Practical Solid-State Lithium Batteries With High-Nickel Cathodes: An Interface-Centered Perspective.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

A Planarity-Hindrance Co-Balance Strategy to Develop Antiparallel H-Aggregates With Minimal Absorbance Blueshift for Type I Photodynamic Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
查看所有相关文章

相关实验视频

Updated: May 20, 2025

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.4K

细胞叶形状转换由内部驱动的,导向的力量.

Junrou Huang1, Juan Chen1, Yimin Luo1

  • 1Department of Mechanical Engineering and Materials Science, Yale University, 9 Hillhouse Ave, New Haven, CT, 06511, USA.

Advanced materials (Deerfield Beach, Fla.)
|April 1, 2025
PubMed
概括
此摘要是机器生成的。

科学家们使用液晶模板水凝纤维设计了具有细胞载荷的自我组织矩阵. 这种方法指导细胞的排列和力量的产生,以控制组织形态发生和形状转换 in vitro.

关键词:
活跃的敌人是活跃的敌人.不同类型的异型性异型性生物材料是一种生物材料.形态发生 (morphogenesis) 是一种形态的产生.摄影图案的图案设计

更多相关视频

Control of Cell Geometry through Infrared Laser Assisted Micropatterning
11:04

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Published on: July 10, 2021

3.4K
Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates
09:30

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Published on: June 2, 2022

2.4K

相关实验视频

Last Updated: May 20, 2025

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.4K
Control of Cell Geometry through Infrared Laser Assisted Micropatterning
11:04

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Published on: July 10, 2021

3.4K
Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates
09:30

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Published on: June 2, 2022

2.4K

科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 发展生物学 发展生物学

背景情况:

  • 细胞形态发生涉及集体定向力量驱动组织和器官的形成.
  • 总结这些体外过程对于推进组织工程至关重要.
  • 目前的方法缺乏对细胞组织和力量生成的精确控制.

研究的目的:

  • 开发一种用于制造自我组织的细胞载荷矩阵的新方法.
  • 控制细胞的排列和集体力量的产生,用于工程组织的发展.
  • 为了证明在复合组织中预先编程的宏观形状变化的潜力.

主要方法:

  • 使用顺序沉积制造独立的,自我组织的,带有细胞的矩阵.
  • 使用液晶模板的水凝纤维,通过接触指导和固体相互作用来直接指导细胞的方向.
  • 通过枯竭相互作用控制水凝纤维的方向与流量或边界线索和微观结构.
  • 使用散射和显微镜探测纤维微结构.

主要成果:

  • 水凝纤维成功地引导嵌在原基质中的细胞,形成多层结构.
  • 均对齐的细胞矩阵表现出面向的细胞施加引力,导致优先矩阵收缩.
  • 细胞重塑导致了矩阵密集化和异性质的发展.
  • 证明了扩展,以创建任意的平面内细胞模式,以协调力量和形状变化.

结论:

  • 在工程组织中建立了一种控制力生成的新方法.
  • 细胞的初始定向场对于操纵形状转换至关重要.
  • 这种方法为创建具有预编程功能的复杂,自我组织的细胞结构提供了一条新的途径.