使用手持式共聚焦拉曼光谱在皮肤中的基础化品配方的非侵入性深度分析
Valerie Xinhui Teo1, Renzhe Bi1, Sze Han Lee2,3
1Translational Biophotonics Lab, A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
Journal of biophotonics
|April 10, 2025
概括
同焦拉曼光谱 (CRS) 不侵入性地测量皮肤陶胺水平. 基于陶胺的保湿剂在角层中比水性保湿剂保持更高的保湿度,这是LCMS验证的.
科学领域:
- 皮肤病学 皮肤病学
- 生物物理学的生物物理.
- 分析化学 分析化学
背景情况:
- 评估皮肤水分的常规方法,如透皮水分流失 (TEWL) 和角膜测量,受环境条件的影响.
- 缺乏体内方法来量化皮肤中的胺含量.
- 了解胺的吸收和保留对于有效的护肤配方至关重要.
研究的目的:
- 评估手持式Confocal Raman Spectroscopy (CRS) 系统的实用性,用于对胺基和水基保湿剂进行非侵入性分析.
- 为了研究不同保湿剂配方的体内吸收和保留动力学.
- 为了比较CRS的性能与既有分析技术.
主要方法:
- 使用手持式孔焦拉曼光谱 (CRS) 系统测量皮肤胺含量.
- 对40名受试者进行了测量,包括20名健康人群和20名阿托皮性皮肤炎患者.
- 皮肤陶胺水平在保湿剂应用后的不同时间点被分析,并使用液态染色学质谱法 (LCMS) 进行验证.
主要成果:
- 与水性乳相比,基于胺的乳在角质层中延长了胺的保留时间,特别是在应用后24小时.
- 手持式CRS提供了对保湿剂吸收和保留的非侵入性体内测量.
- 对陶胺NP的LCMS的验证在健康受试者中显示出高相关性 (r=0.96).
结论:
- 手持式共聚焦拉曼光谱是一种有前途的工具,用于非侵入性评估护肤配方.
- 这项技术可以通过准确评估保湿剂的有效性来加强个性化护肤解决方案的开发.
- 这项研究强调了基于陶胺的配方在皮肤屏障中的优越保留.
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