Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Allergic Reactions02:06

Allergic Reactions

27.2K
Overview
27.2K
Epistasis Analysis01:09

Epistasis Analysis

4.8K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Tinnitus severity and hearing loss: mechanistic insights and future directions.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Causal Effects Between Anxiety-Depressive and Subjective Tinnitus in Europe: A Bidirectional Mendelian Randomization Study.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2025
Same author

Migraine and cochlear disease: A 2-sample bidirectional Mendelian randomized study.

Medicine·2025
Same author

Causal relationships between brain functional networks and tinnitus: A bidirectional 2-sample Mendelian randomization study.

Medicine·2025
Same author

Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy.

ACS nano·2024
Same author

Engineering PTS-based glucose metabolism for efficient biosynthesis of bacterial cellulose by Komagataeibacter xylinus.

Carbohydrate polymers·2024

相关实验视频

Updated: May 13, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

1.5K

多组学:对过敏性鼻炎的双样本,双向,多变量和介导的门德尔随机化分析.

Cheng Zhong1, Li-Hua Wang2, Hao-Peng Zhang2

  • 1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
|April 14, 2025
PubMed
概括

影响免疫细胞,血脂质体和代谢物的遗传因素与过敏性鼻炎 (AR) 风险有关. 这项门德尔随机化研究证实了单向因果关系,突出了AR的潜在治疗点.

关键词:
过敏性鼻炎是一种过敏性鼻炎.原因关系是因果关系.门德尔的随机化多种组合的多种组合.

更多相关视频

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.2K

相关实验视频

Last Updated: May 13, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

1.5K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.2K

科学领域:

  • 免疫学 免疫学 免疫学
  • 代谢学 代谢学 代谢学
  • 遗传学 是一个遗传学.

背景情况:

  • 过敏性鼻炎 (AR) 是一种普遍存在的疾病,具有复杂的潜在机制.
  • 了解免疫反应,脂质代谢和代谢特征之间的相互作用对AR至关重要.

研究的目的:

  • 在过敏性鼻炎的背景下,研究免疫细胞,血脂质体和血代谢物之间的因果关系.
  • 用双向的门德尔随机化方法来确定这些关系的方向性.

主要方法:

  • 使用了一种两样双向多变量和介导的门德尔随机化 (MR) 方法.
  • 采用了来自五个全基因组关联研究 (GWAS) 数据集的遗传数据.
  • 应用反变量加权 (IVW),加权中位数和MR-Egger灵敏度分析.

主要成果:

  • 在免疫细胞,血脂质体和影响AR风险的血代谢物之间显示出显著的遗传相关性.
  • 证实了单向因果影响,没有反向因果关系的证据.
  • 敏感性分析证实了研究结果的稳定性和无性.

结论:

  • 免疫细胞,血脂质体和代谢物中的遗传倾向显著影响过敏性鼻炎的发展.
  • 研究结果表明,这些因素是AR病变发生的关键因素.
  • 需要对不同种群进行进一步的研究,以阐明具体的机制.