植物性饮食和心血管事件:一种蛋白质学方法来检查潜在的途径
Hyunju Kim1, Jingsha Chen2, Brenton Prescott3
1Department of Epidemiology, University of Washington, Seattle, WA, United States; Cardiovascular Health Research Unit, Department of Medicine, University of Washington School of Public Health, Seattle, WA, United States.
The Journal of nutrition
|April 14, 2025
概括
植物性饮食可能会降低心血管疾病 (CVD) 的风险. 蛋白质组学确定了与心血管疾病相关的特定蛋白质,提供了对饮食疾病途径和潜在预防策略的见解.
科学领域:
- 心血管研究的心血管研究.
- 营养科学 营养科学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 植物性饮食与降低心血管疾病 (CVD) 风险有关.
- 蛋白质组学提供了一种方法来理解这种关联背后的生物机制.
研究的目的:
- 调查先前发现的植物性饮食相关蛋白质与发生的心血管疾病之间的关联.
- 在ARIC和FHS后代队伍中使用大规模蛋白质组学来研究这些与心血管疾病亚型相关的关联.
主要方法:
- 发现分析涉及来自ARIC研究的9078名参与者,使用Cox比例危险回归.
- 对1279名来自FHS Offspring队列的参与者进行了复制分析.
- 评估了73种植物性饮食相关蛋白质与发生心血管疾病,冠状动脉疾病,心力衰竭和中风之间的关联.
主要成果:
- 在ARIC研究中,73种蛋白质中有26种与发生的心血管疾病有显著的关联.
- 像可溶性先进糖化末端产品特定受体,血栓松丁-2 (THBS2) 和N-终端亲BNP等蛋白质与心血管疾病和心力衰竭有显著的关联.
- 在FHS后代队列中的复制分析支持了其中一些发现.
结论:
- 鉴定的蛋白质突出显示了潜在的生物学途径,解释了植物性饮食与心血管疾病之间的联系.
- 这些发现有助于理解饮食相关心血管健康的分子基础.
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