米兰系统 SUMP 分类:5年诊断性能
Henri Lagerstam1,2, Erkka Tommola1,2, David Kalfert3
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Diagnostic cytopathology
|May 6, 2025
概括
不确定恶性潜力的唾液腺瘤 (SUMP) 带来了诊断上的挑战. 我们为期5年的研究发现,恶性瘤的风险低于预期,细胞/细胞类亚型和男性的风险更高.
科学领域:
- 细胞病理学 细胞病理学
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 唾液腺瘤表现出显著的细胞形态重叠.
- 米兰唾液腺细胞病理报告系统 (MSRSGC) 包括一个不确定的恶性潜在瘤 (SUMP) 的类别,以应对诊断挑战.
研究的目的:
- 评估SUMP类别在唾液腺细针志向 (SG-FNA) 的表现.
- 为了确定SUMP病例及其亚型的恶性瘤 (ROM) 风险.
- 分析患者人口统计学 (年龄,性别) 对ROM的影响.
主要方法:
- 在2018-2022年期间诊断的SG-FNA的100个SUMP病例的回顾性分析.
- 组织学随访数据审查到2024年5月.
- 将SUMP病例分为细胞形态学亚型 (细胞/细胞,基细胞) 的分类,并计算ROM,瘤风险和工作流程时间表.
主要成果:
- 在SUMP病例中,恶性瘤 (ROM) 的总体风险为23.2%,低于MSRSGC参考值.
- 瘤细胞/瘤细胞类亚型的ROM (35.0%) 与基质细胞类亚型 (18.4%) 相比较高.
- 男性的ROM比女性的ROM高 (总体为26.9%,细胞/细胞类为40.0%) (总体为16.2%,细胞/细胞类为14.3%).
结论:
- 在我们的实践中,SUMP类别的ROM值低于预期.
- 在SUMP分类中,细胞/细胞类亚型与恶性瘤的更高风险有关.
- 在男性和30-69岁的个人中观察到更高的ROM.
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