冠状腺形态的空间和时间变化与长期太空飞行相关.
Charles Bélanger Nzakimuena1, Marissé Masís Solano1,2, Rémy Marcotte-Collard3
1Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.
Investigative ophthalmology & visual science
|May 7, 2025
概括
宇航员在太空飞行期间经历了状腺厚度和斑点血管度的增加. 这些发现揭示了状血管中的脉动性变化,为太空飞行相关的神经眼综合征提供了洞察力.
科学领域:
- 眼科医生 眼科 眼科
- 太空医学 太空医学
- 医疗成像医学成像
背景情况:
- 太空飞行与神经眼部变化有关,包括太空飞行相关的神经眼部综合征 (SANS).
- 准确量化胆道变化对于理解SANS至关重要.
- 深度学习为分析眼睛结构提供先进的图像细分功能.
研究的目的:
- 扩展深度学习用于光学连贯性断层扫描 (OCT) 斑点成像中的胆体量化.
- 描述太空飞行期间黄斑冠状腺的脉动和拓变化.
- 为了研究长时间暴露在微重力中后的胸腔变化.
主要方法:
- 从宇航员在太空飞行前,期间和之后对OCT黄斑视频和卷进行分析.
- 微调深度学习模型以实现精确的胆管细分.
- 血管性的量化和时间依赖和空间平均变量的统计分析.
主要成果:
- 观察到平均胆道厚度和光面积 (LA) 的显著增加.
- 脉动性LA在太空飞行期间显著增加.
- 在黄斑区域,胆体积,亮面体积和胆体血管度指数显著增加.
结论:
- 长时间暴露在微重力中会诱导胆管中局部脉动性变化.
- 冠状血管扩大,在黄斑区域内占据较大的相对空间.
- 开发的方法为研究与太空飞行相关的眼睛风险和对策提供了新的工具.
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