暴露基因所带来的心血管风险
Andreas Daiber1, Sanjay Rajagopalan2, Marin Kuntic1
1Department of Cardiology - Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; German Centre for Cardiovascular Research (DZHK), partner site Rhine-Main, Mainz, Germany.
慢性非传染性疾病 (NCD) 是全球主要的健康威胁. 暴露组概念有助于理解环境对健康的影响,指导诸如动脉样硬化等疾病的预防医学.
科学领域:
- 环境健康科学 环境健康科学
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 慢性非传染性疾病 (NCD) 导致全球三分之二的死亡.
- 污染,压力和气候变化等环境因素对非传染性疾病有很大影响.
- 暴露组概念将环境暴露与健康结果相结合.
研究的目的:
- 审查环境对健康和疾病的影响.
- 解释暴露组概念及其测量方法.
- 讨论暴露性生物标志物及其在动脉样硬化中的作用.
主要方法:
- 使用全球疾病负担研究数据的文献综述.
- 解释暴露组概念及其子类别.
- 讨论暴露性测量技术和已识别的生物标志物.
主要成果:
- 环境暴露是非传染性疾病和过早死亡的主要驱动因素.
- 暴露性研究确定了与动脉样硬化发展相关的生物标志物.
- 病理生理路径包括压力,氧化压力,炎症和昼夜调节失调.
结论:
- 暴露组概念对于理解环境与健康的联系至关重要.
- 暴露性研究为非传染性疾病的预防医学策略提供了信息.
- 了解暴露组对于心血管疾病研究和治疗至关重要.
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