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大脑中NEGR1的升高会诱导焦虑或类似抑郁的表型和突触功能障碍.

Ya-Qi Zhang1,2,3, Qing Zhang4,5, Yi Yang1,2,3

  • 1State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Molecular psychiatry
|May 17, 2025
PubMed
概括

与抑郁症相关的特定基因变体 (rs3101339) 增加了NEGR1的表达. 在小鼠大脑中这种基因过度表达会导致焦虑,抑郁和突触功能受损,这表明在心理健康障碍中发挥了作用.

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