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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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解读系统炎症反应指数和脊柱骨密度之间的值和细分非线性关联:来自大规模人口研究的见解

Muradil Mardan1, Ze-Yu Lu1, Qing-Yin Xu1

  • 1Spine Center, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

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概括

系统性免疫炎症指数 (SIRI) 显示,与脊髓骨矿物质密度 (BMD) 有着复杂的联系. 年龄,高血压和糖尿病改变了这种关系,这表明SIRI可能表明骨质疏松症风险.

关键词:
骨健康 骨健康 骨健康炎症生物标志物 炎症生物标志物骨质疏松症是一种骨质疏松症.这是一项以人口为基础的研究.脊髓骨矿物质密度 脊髓骨矿物质密度系统性炎症反应指数

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科学领域:

  • 免疫学 免疫学 免疫学
  • 老年学是一门学科.
  • 内分泌学 在内分泌学.

背景情况:

  • 系统性免疫炎症指数 (SIRI) 是从中性粒细胞,单细胞和淋巴细胞计数中获得的,它在系统性炎症中的作用越来越被认可.
  • 骨矿物质密度 (BMD) 是骨健康的关键指标,其下降与骨折风险增加有关.

研究的目的:

  • 在大量的成年人群中调查SIRI和脊柱BMD之间的关联.
  • 评估年龄,高血压和糖尿病如何影响SIRI和脊柱BMD之间的关系.

主要方法:

  • 一项横截面研究分析了13950名20岁及以上的参与者的数据.
  • 从完整血清数据计算SIRI,并使用双能X射线吸收计 (DXA) 测量脊柱BMD.
  • 采用了线性回归,通用添加模型和细分回归分析,包括子组分析.

主要成果:

  • 鉴定出SIRI对脊柱 BMD 的值效应为0.68.
  • 在这个值以下,SIRI与脊柱BMD负相关 (β = -0.0412,P = 0.0494).
  • 在值以上,SIRI与脊髓骨质量相关 (β = 0.0079,P < 0.0001),在老年人和患有高血压或糖尿病的人群中观察到更强烈的关联.

结论:

  • 在SIRI和脊柱BMD之间存在一个细分的,非线性关系.
  • 年龄,高血压和糖尿病显著改变了这一关联.
  • SIRI可以作为评估骨质疏松风险的潜在生物标志物.