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Updated: Jun 12, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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Published on: July 14, 2016

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选择的基化合物在翻译后调节HTRA1的丰度和活性,可能通过在三元体接口的相互作用

John D Hulleman1, Seungje Jeon2, Sofia Bali3,4

  • 1Department of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6 St. SE, Minneapolis, Minnesota, 55455, United States.

bioRxiv : the preprint server for biology
|June 4, 2025
PubMed
概括

高温要求蛋白A1 (HTRA1) 对于眼睛健康至关重要,并与与年龄相关的黄斑退行症 (AMD) 有关. 研究人员选化合物,发现芝加哥天空蓝6B增强HTRA1水平,为AMD提供潜在的治疗途径.

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