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相关概念视频

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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相关实验视频

Updated: Jun 21, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

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Published on: December 28, 2010

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在并发的TMS-fMRI中进行切片间刺激.

J B Jackson1, C L Scrivener2, M M Correia1

  • 1MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Rd, Cambridge CB2 7EF, UK.

Journal of neuroscience methods
|June 8, 2025
PubMed
概括
此摘要是机器生成的。

同步跨磁刺激 (TMS) 与功能性MRI (fMRI) 是可行的,使用切割间隙,最大限度地减少数据工件. 这种技术可以灵活地定时TMS脉冲和MRI采集用于大脑研究.

关键词:
同时进行的TMS-fMRI.间切片之间的切片.信号丢失 信号丢失这是一个TMS工件.在TMS的频率上.这是一个TSNR.

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Last Updated: Jun 21, 2026

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科学领域:

  • 神经成像是一种神经成像.
  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程

背景情况:

  • 同时的跨磁刺激 (TMS) 和功能磁共振成像 (fMRI) 能够在大脑行为关系中推断因果关系.
  • TMS脉冲可以将文物引入fMRI数据中,需要文物减轻策略.
  • 切片间TMS-fMRI,在MRI切片采集间隙期间传递TMS脉冲,提供了一个潜在的解决方案.

研究的目的:

  • 提供关于无工件的TMS-fMRI所需的切割间隙的指导.
  • 为研究人员开发一个框架和代码来测试他们的TMS-fMRI协议.
  • 量化TMS脉冲对fMRI数据质量的影响.

主要方法:

  • 使用西门子3T Prismafit扫描仪采集TMS-fMRI数据,该扫描仪具有多频段序列 (因数=2).
  • 使用球形幻影,与与切片激发 (-100毫秒到+100毫秒) 相比,在不同时间传递的TMS脉冲来量化信号丢失和时间信号噪声比率.
  • 实验包括37.5毫秒/100毫秒的切割间隙,每体积高达3个脉冲,以及TMS专用表面线圈,在人类参与者身上重复进行子集.

主要成果:

  • 当TMS脉冲被应用时,从切片激发至少-20 ms / +50 ms时,观察到最小的fMRI数据污染.
  • 切割间TMS-fMRI方法被证实与10 HzTMS兼容.
  • 数据质量受到刺激器强度,切片方向和TMS脉冲数量的影响.

结论:

  • 一个10Hz的TMS切片间协议是可行的,数据污染最小.
  • 超过10Hz的刺激频率需要更短的切片间隙或切片获取时间.
  • 研究人员必须考虑刺激器强度,切片方向和脉冲数,以获得最佳的TMS-fMRI协议设计.