Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

7.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
7.2K
The DNA Helix01:07

The DNA Helix

25.7K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
25.7K
DNA Packaging00:58

DNA Packaging

105.9K
Overview
105.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Role of Metal Complexation in the Unfolding Energetics of a Nudix Hydrolase.

Biochemistry·2026
Same author

Polymer-networked engineered nanoparticles are primitives for neuromorphic computing.

The Journal of chemical physics·2026
Same author

Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.

ACS applied materials & interfaces·2026
Same author

Interpretable Deep Learning for Single-Molecule Nanopore Fingerprinting Using Physics-Guided Preprocessing.

ACS sensors·2026
Same author

Enabling global-scale nucleic acid repositories through versatile, scalable biochemical selection from room-temperature archives.

Nature communications·2026
Same author

DNA origami vaccines program antigen-focused germinal centers.

Science (New York, N.Y.)·2026
Same journal

Probing Charge-Controlled Inter-Domain Flexibility: Integrating Experimental and Coarse-Grained Approaches.

Journal of chemical information and modeling·2026
Same journal

FragScan: A Quantitative Fragment Scanning Strategy for Rational Drug Discovery.

Journal of chemical information and modeling·2026
Same journal

GeoPep: A Geometry-Aware Masked Language Model for Protein-Peptide Binding Site Prediction.

Journal of chemical information and modeling·2026
Same journal

Interaction Persistence-Based Identification of Key Binding Residues in the Cellular Retinol-Binding Protein 1 Complex.

Journal of chemical information and modeling·2026
Same journal

Tree-Guided Graph Neural Networks with Multilevel Optimization for Protein-Protein Interaction Prediction.

Journal of chemical information and modeling·2026
Same journal

ASO-RASAR: A Read-Across Framework for Predicting Antisense Oligonucleotide Gapmer Activity Across Target Genes.

Journal of chemical information and modeling·2026
查看所有相关文章

相关实验视频

Updated: Sep 18, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.7K

使用卷积神经网络在TEM图像中描述DNA原始结构纳米结构.

Xingfei Wei1, Qiankun Mo1, Chi Chen2

  • 1Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.

Journal of chemical information and modeling
|June 20, 2025
PubMed
概括
此摘要是机器生成的。

卷积神经网络 (CNN) 模型现在可以描述DNA原始结构纳米结构. 精心调整的VGG16模型在传输电子显微镜图像中识别结合位点时显示出高精度.

更多相关视频

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.7K
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.3K

相关实验视频

Last Updated: Sep 18, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.7K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.7K
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.3K

科学领域:

  • 纳米技术 纳米技术
  • 生物医学工程 生物医学工程
  • 计算科学 计算科学

背景情况:

  • 人工智能 (AI) 模型加速材料设计.
  • 在生物医学中,DNA原始结构纳米结构对于可编程自组装至关重要.
  • 描述纳米结构有助于理解它们的功能和应用.

研究的目的:

  • 为了对九个卷积神经网络 (CNN) 模型的性能进行基准测试,用于表征DNA原始结构纳米结构.
  • 评估CNN模型在传输电子显微镜 (TEM) 图像中确定结合数的能力.
  • 使用模拟和实验数据,比较预训练和微调CNN模型的准确性.

主要方法:

  • 在720个粗粒度分子动力学 (MD) 模拟图像上预训练了9个CNN模型 (AlexNet,GoogLeNet,VGG16,VGG19,ResNet18,ResNet34,ResNet50,ResNet101,ResNet152).
  • 微调预训练CNN模型,使用146张实验TEM图像的数据集.
  • 基于准确性,计算时间和模型大小的基准模型性能.

主要成果:

  • 所有的CNN模型都表现出类似的计算时间要求.
  • 在预训练模型中,ResNet50和VGG16在测试MD图像上取得了最高的准确性.
  • 精心调整的VGG16与实验TEM图像达到了最高的一致性,表明了卓越的表征能力.

结论:

  • 精心调整的VGG16 CNN模型可以从TEM图像中高效准确地描述DNA原木纳米结构中的结合位数.
  • 这种由人工智能驱动的方法为分析大型图像数据集中的纳米结构提供了一种快速的方法.
  • 该研究强调了人工智能在推进材料设计和纳米医学应用方面的潜力.