相关实验视频
Updated: Sep 18, 2025
10:05
In vivo 19F MRI for Cell Tracking
Published on: November 25, 2013
14.9K
在瘤中显示"组装-拆卸"级联与"关闭-关闭"磁共振成像信号
Hai-Dong Xu1, Xianbao Sun1, Zheng Huang2
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China.
Journal of the American Chemical Society
|June 24, 2025
概括
研究人员开发了一种新的加多探测器, 该探测器使用磁共振成像 (MRI) 可视化"组装-拆卸"级联,克服了动态监测的先前限制.
科学领域:
- 生物医学工程
- 纳米技术
- 医学成像
背景情况:
- "组装-拆卸"级联对于瘤诊断至关重要,但缺乏实时体内监测能力.
- 现有的方法难以平衡透深度和动态过程的实时跟踪.
- 整合这两种功能以实现体内级联可视化仍然是一个未解决的挑战.
研究的目的:
- 开发一种新的加多 (Gd) 探测器,用于实时实体监测瘤治疗中的"组装-拆卸"级联.
- 通过MRI实现活体体内的动态级联过程的集成实时显示.
- 克服当前预测监测策略的局限性.
主要方法:
- 开发一个Gd探头,Cys(StBu) -Asp-Asp-Asp-Lys-Lys(DOTA(Gd)) -CBT (Gd-AD),用于T1加权的1H磁共振成像 (MRI).
- 在降解条件下利用CBT-Cys点击反应进行纳米粒子组装.
- 在纳米粒子分解过程中采用肠酶 (ENTK) 裂变.
- 用加密控制探针 (Gd-A) 进行比较研究以验证.
主要成果:
- 在体外和体内,Gd-AD显示了"关闭-关闭"T1加权的1HMRI信号变化,反映了"组装-拆卸"级联.
- 组装导致MRI信号增强 (59.3%在细胞中,25.4%在瘤中);拆卸导致信号减少 (23.4%在细胞中,15.2%在瘤中).
- 在1小时的瘤成像中,Gd-AD显然显示出"关闭"信号,与对照Gd-A的"关闭"信号不同.
结论:
- 开发的Gd-AD探测器可以实时对瘤治疗中的"组装-拆卸"级联进行可视化.
- 这一战略结合了透深度和实时监测,解决了当前预测方法中的关键缺口.
- 这些发现为通过动态级联监测优化基于纳米药物的瘤治疗提供了一个有希望的平台.
相关概念视频
01:24Magnetic Resonance Imaging
7.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.3K
01:05Atomic Nuclei: Magnetic Resonance
766
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
766
01:27Imaging Studies IV: Magnetic Resonance Imaging
60
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
60