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Updated: Sep 18, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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使用CLIPPERs在大肠杆菌中向蛋白质降解

Matylda Anna Izert-Nowakowska1, Maria Magdalena Klimecka1, Anna Antosiewicz1

  • 1Structural Biology Group, Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland.

EMBO reports
|June 25, 2025
PubMed
概括

研究人员使用降解和ClpXP蛋白酶开发了一种针对细菌蛋白质降解的新方法. 这种方法可以加速抗微生物研究和蛋白质功能研究,而无需进行遗传修饰.

关键词:
这就是ClpXPP.降解器降解器降解器格罗埃尔 (GroEL) 是一个古老的城市.蛋白质溶解是一种蛋白质溶解.有针对性的蛋白质降解.

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