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驳斥辅助生殖技术与自闭症谱系障碍之间的关联:一项案例对照研究

Ronit Kol1, Liat Lerner Geva1, Meirav Shaham2

  • 1Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.

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概括

与典型发育儿童相比,患有自闭症谱系障碍 (ASD) 的儿童使用辅助生殖技术 (ART) 并没有显著差异. ART与ASD的性别或严重程度没有相关性,这令人担心有关联系的担忧.

关键词:
辅助生殖技术 (ART) 是一种助孕技术.自闭症谱系障碍 (ASD)在体外受精.不孕不育 不孕不育 不孕不育

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科学领域:

  • 神经发育障碍 神经发育障碍
  • 生殖医学 生殖医学

背景情况:

  • 自闭症谱系障碍 (ASD) 和辅助生殖技术 (ART) 的发病率同时上升.
  • 有关ART与ASD发展之间潜在的关联存在担忧.

研究的目的:

  • 通过病例控制研究来调查ART和ASD之间的关联.
  • 为了确定ART是否影响ASD的性别分布或严重程度.

主要方法:

  • 病例对照研究比较了319名患有自闭症的儿童和319名年龄相匹配的典型发育儿童.
  • 分析根据性别,ART类型和ASD严重程度进行了调整.
  • 统计分析包括赔率比率和置信区间.

主要成果:

  • 在ASD (8.5%) 和典型发育 (9.4%) 组之间,ART使用率相似.
  • 在ART和ASD诊断之间没有发现显著的关联 (aOR = 0.537,95%CI 0.110-3.383).
  • 激素治疗和体外受精 (IVF) 也没有显示出与ASD有显著的关联.

结论:

  • 与对照组相比,在患有自闭症的儿童中,ART并不比对照组更常见.
  • ART与ASD的性别或严重程度无关.
  • 这些发现令人放心的是,ART和ASD之间没有明显的关联.