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相关概念视频

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

562
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
562
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

871
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
871
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

501
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
501
Local Anesthetics: Chemistry and Structure-Activity Relationship01:27

Local Anesthetics: Chemistry and Structure-Activity Relationship

5.5K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
5.5K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

945
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
945
Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

2.6K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
2.6K

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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3个对话生成型人工智能模型的性能,用于计算局部麻醉剂的最大安全剂量:比较分析.

Mélanie Suppan1,2, Pietro Elias Fubini1,2, Alexandra Stefani1,2

  • 1Division of Anaesthesiology, Department of Acute Care Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, Geneva, 1211, Switzerland.

JMIR AI
|July 3, 2025
PubMed
概括

像ChatGPT,Copilot和Gemini这样的生成人工智能模型尚未可靠地计算局部麻醉剂 (LA) 的最大安全剂量. 目前的AI工具显示出严重的不准确性和风险,强调需要继续依赖临床专业知识,以确保安全的LA管理.

关键词:
在这里,我们可以看到AIAIAI.聊天GPT 聊天GPT 聊天副驾驶员是我们的副驾驶员.双子座是一个双子座.拉拉拉拉拉拉拉拉拉拉拉拉拉拉拉拉拉在法学士 (LLM) 课程中.ML ML 在 ML在NLP中,我们使用了NLP.麻醉学 麻醉学麻醉剂 麻醉剂 麻醉剂人工智能的人工智能是人工智能.人工智能模型的人工智能模型进行比较分析.交谈式生成型人工智能 交谈式生成型人工智能剂量计算剂量计算方法生成型的人工智能 (GAI)大型语言模型这是一种局部麻醉剂.机器学习是机器学习.自然语言处理自然语言处理.神经网络的神经网络的神经网络业绩表现表现的表现表现是什么毒性的毒性 毒性的毒性

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科学领域:

  • 医疗信息学 医疗信息学
  • 麻醉学 麻醉学
  • 人工智能在医学中的应用

背景情况:

  • 生成型人工智能 (AI) 显示出优化医疗决策的潜力.
  • 准确计算最大安全局部麻醉剂 (LA) 剂量在麻醉学中至关重要,以防止局部麻醉系统毒性 (LAST).
  • 目前的LA剂量依赖于经验指南和临床医生的经验,导致变化和错误.

研究的目的:

  • 评估三个生成AI模型 (ChatGPT,Copilot,Gemini) 在计算最大安全LA剂量的有效性和安全性.
  • 确定这些AI模型对LA剂量计算的潜在临床实用性.

主要方法:

  • 一项比较分析使用了10个模拟的临床细节中的51项问卷.
  • 人工智能生成的LA剂量计算与科学验证的参考剂量进行了比较.
  • 进行了量化剂量比较和独立审查员的定性评估.

主要成果:

  • 所有的人工智能模型都产生了与LA计算原则一致的响应,但安全性差异很大.
  • 双子座经常推迟专家或提供剂量超过安全限值140% (SD103%) 的混合物.
  • 聊天GPT (90%不安全,+198%超限) 和Copilot (67%不安全,+217%超限) 的表现不佳,质量评分为"差".

结论:

  • 目前的生成AI模型 (Gemini,ChatGPT,Copilot) 缺乏安全的LA剂量计算所需的准确性和可靠性.
  • 这些AI模型不应该被用作LA剂量的决策工具.
  • 临床医生必须继续依赖专业知识和患者评估,以确保安全的LA给药,直到得到验证的AI解决方案出现.