阿片恐惧症:错误的信息,误解,误解,观点和后果
1Department of Chemistry and Biochemistry, University of Northern Iowa, Cedar Falls, Iowa 50614, United States.
ACS pharmacology & translational science
|July 17, 2025
概括
即使在医疗监督下,短期使用阿片类药物治疗急性疼痛,也被错误地归咎于阿片类药物流行. 限制处方并不能减少过量服用的死亡,这与人们普遍认为的相反.
科学领域:
- 疼痛管理 疼痛管理
- 成 药物 药物 药物 药物
- 公共卫生政策 公共卫生政策
背景情况:
- 一个常见的信念将短期使用阿片类药物 (≤7天) 治疗急性疼痛与阿片类药物使用障碍 (OUD) 联系起来.
- 这种看法推动了避免或严重限制处方阿片类药物的策略,特别是在手术后.
- 人们还认为,限制处方将减少阿片类药物过量死亡.
研究的目的:
- 审查和分析挑战短期阿片类药物使用导致OUD的叙述的证据.
- 检查大大减少或消除处方阿片类药物使用对阿片类药物流行病的影响.
- 讨论组织,研究人员和临床医生的关于阿片类药物处方实践的观点.
主要方法:
- 文学评论和评论. 文学评论和评论.
- 对有关阿片类药物使用和成的现有证据的分析.
- 探讨疼痛管理和成的各种利益相关者的观点.
主要成果:
- 实质性的证据与短期医疗阿片类药物使用是阿片类药物流行病的主要驱动因素的观点相矛盾.
- 严格限制处方阿片类药物可能无法有效减少阿片类药物过量死亡.
- 主流的叙述可能过于简化了导致阿片类药物使用障碍的复杂因素.
结论:
- 短期阿片类药物处方和广泛的阿片类药物使用障碍之间的联系没有得到实质证据的支持.
- 专注于限制阿片类药物处方的政策可能是错误的,并且未能解决阿片类药物危机的根本原因.
- 需要采用细微的方法,考虑基于证据的疼痛管理以及打击阿片类药物成和过量服用的策略.
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