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Updated: Sep 11, 2025

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
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Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

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在酵母和人类单细胞中使用转移学习进行细胞年龄预测的协议.

Subhadeep Duari1, Vishakha Gautam1, Gaurav Ahuja2

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi 110020, India.

STAR protocols
|August 12, 2025
PubMed
概括

这项研究引入了一种计算机视觉协议,使用显微镜图像来预测细胞年龄. 该方法分析细胞形态和生物活性,适应性跨物种,如酵母和人类纤维细胞.

关键词:
细胞生物学 细胞生物学计算机科学 计算机科学

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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