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相关概念视频

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Parental Care00:55

Parental Care

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Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
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相关实验视频

Updated: Sep 10, 2025

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
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Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

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功能性后果 父亲的怀孕前的饮酒

Sahir Hussain1, Darren Day1, Bart Ellenbroek2

  • 1Te Herenga Waka-Victoria University of Wellington, Wellington, New Zealand.

Current topics in behavioral neurosciences
|August 23, 2025
PubMed
概括

父亲在受孕前的饮酒会对后代产生负面影响,导致世代间的行为和分子变化. 表观遗传机制可以解释这些影响是如何遗传的.

科学领域:

  • 神经生物学
  • 遗传学
  • 表观遗传学

背景情况:

  • 酒是一个重要的公共卫生和经济问题.
  • 研究主要集中在酒精的直接影响,
  • 遗传因素并不能完全解释酒精使用障碍 (AUD) 的风险或类似FASD的症状.

研究的目的:

  • 审查父子酒精消费 (PPAC) 的代际和跨代影响.
  • 概述了跨世代的观察结果.
  • 探索这些变化的表观遗传机制.

主要方法:

  • 对父亲的酒精暴露和后代结果的文献综述.
  • 对涉及生殖系传播的表观遗传机制的分析.
  • 检查后代的行为和分子变化.

主要成果:

  • 父亲大量饮酒预示着青少年早些时候和大量饮酒的后代.
  • 后代表现出行为和分子变化.
  • 表观遗传在这些影响的传播中起着作用.

结论:

  • 父亲在怀孕前的饮酒会对代际和跨代人产生持久的影响.

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相关实验视频

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  • 表观遗传机制对于了解父母经验如何影响后代至关重要.
  • 需要进一步的研究来充分阐明这些遗传途径.