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Peripherally and Centrally Acting Muscle Relaxants: A Comparison01:09

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Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
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相关实验视频

Updated: Jan 18, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
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渐进性肌肉松对疼痛和睡眠的影响:随机对照研究.

Gamze Bolattürk1, Emine Kol2

  • 1Fundamentals of Nursing Department, Suleyman Demirel University Nursing Departmant, Isparta, Turkey.

Pain management nursing : official journal of the American Society of Pain Management Nurses
|September 7, 2025
PubMed
概括

渐进性肌肉松 (PMR) 显著降低了手术后疼痛,并改善了心脏开放手术患者的睡眠质量. 建议护士将这种技术纳入标准术后护理,以控制疼痛和睡眠.

关键词:
开放式心脏手术是什么疼痛水平 疼痛水平渐进式的肌肉松可以使肌肉放松.睡眠质量 睡眠质量

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科学领域:

  • 心血管外科心血管外科
  • 疼痛管理 疼痛管理
  • 睡眠医学 睡眠医学

背景情况:

  • 手术后的疼痛和睡眠质量受损是患者在心脏开放手术后面临的重大挑战.
  • 有效的非药物干预对于改善患者的治疗结果和康复至关重要.
  • 渐进性肌肉放松 (PMR) 是一种被广泛认可的放松技术,对疼痛和睡眠有潜在的益处.

研究的目的:

  • 为了评估渐进性肌肉松 (PMR) 在治疗术后疼痛方面的有效性.
  • 评估PMR对接受开放心脏手术的患者睡眠质量的影响.
  • 为了比较接受PMR和接受标准术后护理的患者之间的结果.

主要方法:

  • 一个单一中心的随机对照试验,涉及60名心脏开放手术患者.
  • 患者被分为一个接受PMR的实验组 (n=30) 和接受通常护理的对照组 (n=30).
  • 使用麦吉尔疼痛问卷 (SF-MPQ) 的简短形式评估疼痛水平,并通过理查德-坎贝尔睡眠问卷 (RCSQ) 测量睡眠质量.

主要成果:

  • 实验组在术后第3天的疼痛显著减少,从9.36点降至1.50点 (p<0.001).
  • 实验组的睡眠质量显著提高,在术后第三天达到545.83分.
  • 在整个研究期间,在PMR组和对照组之间观察到疼痛程度和睡眠质量的显著差异.

结论:

  • 渐进性肌肉松 (PMR) 是一种有效的干预措施,用于减少心脏开放手术患者的术后疼痛.
  • 在心脏开放手术后,PMR显著改善了睡眠质量.
  • 护士应该考虑将PMR纳入常规的术后护理协议,以控制疼痛和睡眠.