肠道微生物群和自闭症谱系障碍:神经发育,行为和胃肠道相互作用
Zuzanna Lewandowska-Pietruszka1,2, Magdalena Figlerowicz1, Katarzyna Mazur-Melewska1
1Poznan University of Medical Sciences, Department of Infectious Diseases and Child Neurology, 60-572 Poznan, Poland.
Nutrients
|September 13, 2025
概括
自闭症谱系障碍 (ASD) 的肠道细菌受到传递方式和饮食的影响. 微生物特征与适应性行为和胃肠道问题相关,这表明针对微生物群的干预措施可能会改善ASD症状.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出社会沟通缺陷,重复行为和频繁的胃肠道问题.
- 肠道微生物群的改变越来越多地与ASD病理生理学和胃肠道功能障碍有关.
- 详细的微生物特征及其在ASD中的临床相关性需要进一步研究.
研究的目的:
- 分析ASD儿童的肠道微生物群组成.
- 调查微生物特征和临床特征之间的相关性,包括适应性功能和胃肠道症状.
- 探索分娩方式,饮食和人口统计学对ASD肠道微生物群的影响.
主要方法:
- 来自45名被诊断患有自闭症的儿童 (2-18岁) 便样本的16S rRNA基因测序.
- 临床评估包括ASD亚型,适应性行为 (Vineland尺度),胃肠道症状 (罗马第四标准),饮食和人口统计数据.
- 使用统计分析,将微生物群的个人资料与临床数据相关联.
主要成果:
- 肠道微生物群的组成受到分娩方式,年龄,性别和饮食的显著影响.
- 阴道分娩与有益细菌有关,而剖腹产与致病性细菌相关.
- 微生物多样性和特定属与适应性行为和胃肠道症状严重程度相关.
- 饮食模式,特别是高卡路里/高蛋白饮食,将微生物群转移到有利于炎症的形状.
- 亲炎性和抗炎性细菌都对神经发育结果产生了可变的影响.
结论:
- 患有自闭症儿童的肠道微生物群受到多因素的影响,并与神经行为和胃肠道表型有关.
- 这些发现支持了针对微生物群的干预措施改善ASD症状的潜力.
- 调节肠道微生物组可能会改善ASD患者的生活质量.
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