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MEK-ERK绑定接口的不对称共进化

Anton V Persikov1, Robert A Marmion2, Stanislav Y Shvartsman3

  • 1Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

The Journal of biological chemistry
|September 13, 2025
PubMed
概括

该研究揭示了MEK蛋白的适应性对接位 (D位) 如何与ERK共同演变,平衡保护功能与信号灵活性. 这种可适应的图案对于MEK-ERK复杂的稳定性和信号动态至关重要.

关键词:
这就是MEK MEK.共同进化的共同进化激酶激酶的作用是什么与蛋白质结合的蛋白质结合一个简短的线性图案.

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