岛屿路由到轨道前皮层使呼吸意识成为可能
Joshua Y Assi1, Stephan Bickel1,2,3, Harly E Greenberg4
1Department of Bioelectronic Medicine, Feinstein Institutes for Medical Research; Manhasset, New York 11030, USA.
medRxiv : the preprint server for health sciences
|September 15, 2025
概括
人类大脑通过岛屿前端电路检测呼吸中断. 这种神经通路帮助我们感知和适应呼吸挑战,为呼吸控制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 人类大脑研究 人类大脑研究
背景情况:
- 了解人类呼吸控制是复杂的,涉及脑干,肺和上皮层区域.
- 呼吸困扰可能源于各种原因,包括脑干功能障碍和呼吸信号的情感解释.
- 现有的动物模型对人类特定的呼吸应急机制提供了有限的洞察力.
研究的目的:
- 研究人类大脑如何检测和响应呼吸中暂时的干扰.
- 为了确定神经回路涉及到意识意识和补偿呼吸挑战.
- 探索大脑上层区域在解释呼吸信号中的作用.
主要方法:
- 在神经外科患者中记录了内皮层活动.
- 使用了一项涉及暂时呼吸挑战的整体感应任务.
- 分析了前脑岛,轨道前皮层和前运动皮层的神经反应.
主要成果:
- 呼吸中断的有意识检测是由前面的insula的早期反应预测的.
- 前半球向轨道前皮层和前运动皮层发送信号以进行评估和补偿.
- 皮层区域显示了灵感努力和空气流的信号特定处理,反映了脑干功能.
结论:
- 确定了一个动态的岛内-正面皮层电路,用于感知和适应呼吸挑战.
- 这个电路对于呼吸意识至关重要,可能与呼吸系统疾病有关.
- 研究结果显示,皮质区域的特定信号处理与呼吸控制有关.
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