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接受减肥手术的甲状腺功能低下患者的不良结果:使用TriNetXX进行的一项回顾性研究
Vandrize Meneghini1,2, Fabyan Esberard de Lima Beltrão1,3,4, George Golovko5
1Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
The Journal of clinical endocrinology and metabolism
|September 19, 2025
概括
预先存在的甲状腺功能低下症增加了减肥手术 (BS) 后的不良结果. 虽然BS可以降低肥胖的风险,但甲状腺功能低下症患者面临更高的并发症,缺陷和骨质疏松症等特定健康问题.
科学领域:
- 内分泌学 在内分泌学.
- 腹部外科手术的结果
- 公共卫生 公共卫生
背景情况:
- 减肥手术 (BS) 对肥胖有效,但对甲状腺功能低下症患者的影响尚不清楚.
- 了解这些结果对于优化患者护理和手术决策至关重要.
研究的目的:
- 为了研究先前存在的甲状腺功能低下症和减肥手术 (BS) 后不良健康结果之间的关联.
- 为了比较患有甲状腺功能低下症和没有甲状腺功能低下症的患者的结果,接受BS.
主要方法:
- 使用 TriNetX 全球协作网络数据库进行回顾性队列研究.
- 倾向性得分匹配用于比较患有肥胖症的患者,这些患者接受了带有和没有甲状腺功能低下症的BS.
主要成果:
- 患有甲状腺功能低下症的患者出现了短期再入院,切口,胆道疾病的风险增加.
- 长期的甲状腺功能低下症与较高的脑血管事件风险,糖尿病,失脂症,跌倒,骨质疏松症,多神经病,低血糖症和维生素缺乏症有关.
- 这些风险在胃绕道手术中加剧.
结论:
- 预先存在的甲状腺功能低下症会增加腹部外科手术后不良结果的风险.
- 尽管增加了风险,但减肥手术仍然为甲状腺功能低下患者提供了与非手术治疗相比,与肥胖相关的结果减少.
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