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Updated: Jan 17, 2026

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预测Caco-2/MDCK内在膜透度从HDM-PAMPA衍生的六甲/水分区系数

Carolin Dahley1, Kai-Uwe Goss2, Andrea Ebert1

  • 1Department of Computational Biology & Chemistry, Helmholtz Centre for Environmental Research (UFZ), Permoserstraße 15, 04318 Leipzig, Germany.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|September 19, 2025
PubMed
概括

准确的六甲/水分区系数 (Khex/w) 对于预测药物膜透性至关重要. HDM-PAMPA方法可靠地确定Khex/w,使候选药物的高通量选成为可能.

关键词:
在Caco-2中使用.这就是HDM-PAMPA.这就是MDCKK的MDCK.十六度甘/水分的分配系数内在膜的透性是内在的可溶性-扩散模型的可溶性-扩散模型.

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