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相关概念视频

Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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Raman Spectroscopy: Overview01:20

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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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相关实验视频

Updated: Jan 17, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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使用空间抵消拉曼光谱成像技术评估不弹性散射测量的深度传感极限的实验方法.

Hugo Tavera1,2, Guillaume Sheehy1,2, Patrick Orsini3

  • 1Polytechnique Montreal, Department of Physics Engineering, Montreal, Quebec, Canada.

Journal of biomedical optics
|September 22, 2025
PubMed
概括

空间偏移拉曼光谱 (SORS) 现在可以预测组织感应深度. 这一进步改善了地下生化检测,用于诸如乳腺癌手术利率评估等应用.

关键词:
拉曼光谱法 拉曼光谱法 拉曼光谱法生物化学 生物化学深度分辨率成像成像技术光是一种光.无弹性散射是一种无弹性的散射.组织光学 组织光学

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相关实验视频

Last Updated: Jan 17, 2026

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科学领域:

  • 频谱学是一种光谱学.
  • 生物医学光学 生物医学光学
  • 化学分析 化学分析

背景情况:

  • 空间偏移拉曼光谱 (SORS) 是一个有前途的技术,用于地下生化分析.
  • 在SORS中空间偏移和传感深度之间的关系还不太清楚,这限制了临床应用,例如乳腺癌手术边际评估.

研究的目的:

  • 开发一种实验方法,以确定SORS中的空间偏移与采样深度之间的关系.
  • 为了能够检测地下生物化学成分,以改善SORS.的临床翻译.

主要方法:

  • 使用定制的超光谱线扫描成像系统进行SORS检测.
  • 采用了具有不同光学特性和厚度的双层幻影 (PDMS/尼龙).
  • 开发了一种使用光谱角度映射仪的技术,根据空间偏移来预测传感深度.

主要成果:

  • 通过高达3毫米的PDMS,证明了底层尼龙层的可检测性.
  • 通过3毫米的脂肪和2毫米的猪脂肪检测出富含蛋白质的组织.
  • 基于顶层光学特性,建立了空间偏移和探测深度之间的相关曲线.

结论:

  • 证明了使用双层幻象来将空间偏移与探测深度相关联的可行性.
  • 开发的技术可以促进SORS的临床翻译,用于瘤检测和边缘评估.