结构连接在对功能大脑网络的遗传影响中的调解作用
medRxiv : the preprint server for health sciences
|September 26, 2025
概括
这项研究揭示了遗传变异如何影响发育期间的大脑结构和功能. 它确定了直接影响大脑网络的特定遗传因素,并通过结构连接间接影响功能连接.
科学领域:
- 神经成像遗传学 神经成像遗传学
- 发育神经科学的发展神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 了解遗传学,大脑结构和功能之间的相互作用对于神经发育研究至关重要.
- 之前的研究已经探讨了这些关系,但因果关系途径仍然复杂,需要进一步调查.
研究的目的:
- 研究结构连接 (SC) 在将遗传变异 (单核酸多态 - SNPs) 与大脑功能连接 (FC) 联系中的调解作用.
- 通过使用因果调解框架,探索神经发育中的这些关系.
主要方法:
- 利用了来自青少年大脑认知发展 (ABCD) 研究的数据,包括SC,FC和来自11,666名受试者的500k个SNP.
- 采用全基因组关联研究 (GWAS) 来识别与SC和FC特征相关的SNP.
- 进行调解分析以确定通过SC对大脑网络的直接和间接遗传影响.
主要成果:
- 确定了直接影响大脑功能网络的特定SNP.
- 揭示了结构连接调解了某些遗传暴露对功能连接的间接影响.
- 证明了遗传变异如何塑造结构和功能大脑网络组织.
结论:
- 遗传变异在神经发育过程中显著影响大脑结构和功能网络组织.
- 结构连接在大脑功能遗传结构中起着关键的调解作用.
- 这项研究为将遗传因素与大规模大脑网络联系起来的因果途径提供了更深入的见解.
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