Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hematopoiesis01:21

Hematopoiesis

8.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.7K
Production of Formed Elements01:34

Production of Formed Elements

3.6K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.6K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

8.3K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.3K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.8K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.8K
Lineage Commitment01:21

Lineage Commitment

4.1K
Commitment is the  process whereby stem cells:
4.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Polyclonal evolution of lymphoproliferative disorders in XLP1.

Journal of human immunity·2026
Same author

BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL.

Blood·2026
Same author

Functional impact of a deep intronic variant in the RPS19 gene detected in a case of Diamond-Blackfan anemia syndrome.

Haematologica·2026
Same author

Biological Features of KLC2 Mutations in Chronic Myeloid Leukemia and Their Contribution to Inducing Drug Resistance.

Oncology research·2026
Same author

Comprehensive molecular and functional analysis of NUTM1-rearranged leukemia.

Blood·2025
Same author

Somatic mutations and clonal evolution in normal tissues and cancer development.

Experimental & molecular medicine·2025

相关实验视频

Updated: Jan 16, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.0K

[克隆性血液形成]

Kenichi Yoshida1

  • 1Division of Cancer Evolution, National Cancer Center Research Institute.

[Rinsho ketsueki] The Japanese journal of clinical hematology
|October 1, 2025
PubMed
概括
此摘要是机器生成的。

克隆性造血,血液干细胞的扩张与突变,在老年人中很常见. 它可以在几十年内导致血液癌症,心血管疾病和其他癌症.

关键词:
克隆性血液形成 (clonal hematopoiesis) 是一种血液形成的过程.驱动器突变的变异遗传背景 遗传背景

更多相关视频

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

9.0K
Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

12.9K

相关实验视频

Last Updated: Jan 16, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.0K
Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

9.0K
Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

12.9K

科学领域:

  • 血液学 血液学 血液学
  • 遗传学 是一个遗传学.
  • 在瘤学瘤学.

背景情况:

  • 克隆性造血包括造血干细胞扩张和驱动基因突变.
  • 它是由于累积体质突变而导致衰老的不可避免的后果.
  • 识别的驱动基因通常与血液性恶性瘤共享.

研究的目的:

  • 总结一下当前对克隆性血液形成的理解.
  • 突出其与衰老和癌症发展的关联.
  • 讨论其在非血液学疾病中的更广泛影响.

主要方法:

  • 关于克隆性血液形成研究的文献综述.
  • 血液造血干细胞中驱动基因突变的分析.
  • 检查从突变获得到疾病发病的时间过程.

主要成果:

  • 克隆性血液形成在老年人中很普遍.
  • 在最初的突变和癌症发病之间存在大约30年的潜伏期.
  • 遗传背景影响了克隆性血液形成的启动和进展.

结论:

  • 克隆性血液形成与血液性恶性瘤有关.
  • 它还导致心血管疾病和固体瘤.
  • 针对驱动器突变的向疗法是未来的前景.