Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.8K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.8K
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

59.3K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Distal Agrin (AGRN) Congenital Myasthenic Syndrome With Mitochondrial Dysfunction.

European journal of neurology·2026
Same author

Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies.

medRxiv : the preprint server for health sciences·2026
Same author

Statins in Genetic Myopathies: A Retrospective Analysis of Safety and Tolerability.

Neurology. Clinical practice·2026
Same author

Congenital myasthenic syndrome: is it time for a name change to genetic myasthenic syndrome?

Brain : a journal of neurology·2026
Same author

Immune-Driven Expression in Inclusion Body Myositis With T-Cell Large Granular Lymphocytic Leukemia.

Annals of clinical and translational neurology·2026
Same author

Expanding the Molecular and Pathologic Spectrum of <i>HSPB8</i> Myopathy and Distal Motor Neuropathy.

Neurology. Genetics·2025

相关实验视频

Updated: Jan 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

636

一个模式识别方法对肌肉病的方法.

Margherita Milone

    Continuum (Minneapolis, Minn.)
    |October 2, 2025
    PubMed
    概括
    此摘要是机器生成的。

    诊断肌肉疾病需要将临床发现与遗传测试和肌肉活检相结合. 准确的诊断这些异质条件对于有效的治疗和改善患者的结果至关重要.

    更多相关视频

    Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
    08:16

    Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

    Published on: March 4, 2014

    33.0K
    Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
    08:36

    Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition

    Published on: August 31, 2017

    11.0K

    相关实验视频

    Last Updated: Jan 6, 2026

    Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
    10:55

    Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

    Published on: October 31, 2025

    636
    Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
    08:16

    Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

    Published on: March 4, 2014

    33.0K
    Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
    08:36

    Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition

    Published on: August 31, 2017

    11.0K

    科学领域:

    • 神经学 神经学
    • 遗传学 遗传学 是一个
    • 病理学 病理学 病理学

    背景情况:

    • 由于基因测试和生物标志物开发的进步,遗传性和获得性肌肉疾病的范围正在扩大.
    • 肌肉疾病可以是孤立的,也可以是多系统性疾病的一部分,这会给诊断带来挑战,特别是当症状模仿其他疾病 (如外围神经病变) 时.
    • 针对特定遗传变异和免疫介导肌肉疾病开发有针对性的疗法凸显了对精确诊断的需求.

    研究的目的:

    • 审查临床因素,肌肉参与模式和诊断工具来诊断肌肉疾病.
    • 强调与肌肉疾病相关的异质性和诊断挑战.
    • 强调准确诊断对患者护理和预后的重要性.

    主要方法:

    • 对临床评估策略的审查.
    • 临床和实验室发现的整合.
    • 讨论包括遗传检测和肌肉活检在内的诊断工具.
    • 在诊断方面考虑人工智能.

    主要成果:

    • 临床评估和综合发现是诊断和治疗肌肉疾病的核心.
    • 基因检测越来越多地用于遗传性肌肉病变,而肌肉活检对于获得性疾病和变异性致病性评估至关重要.
    • 准确的诊断显著影响患者的护理,预后和获得向治疗的机会.

    结论:

    • 准确诊断特定的肌肉疾病对于有效的患者管理和预后至关重要.
    • 与遗传发现相关的患者表型的严格表征是必不可少的.
    • 持续的进步,包括人工智能,正在优化肌肉疾病的诊断过程.