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相关概念视频

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

200
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

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The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
857
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

232
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
232
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

218
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
218
Time Course of Drug Effect01:14

Time Course of Drug Effect

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The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
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Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
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随着时间的推移,使用IFASIS追踪实施决定因素:对阿片类药物治疗计划的多站点分析,实施数字应急管理平台.

Allyson L Dir1, Briana M Patrick2, Sarah Salino3

  • 1Department of Psychiatry, Indiana University School of Medicine, 410 W 10th Street, Indianapolis, IN, 46201, USA. adir@iu.edu.

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|October 11, 2025
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概括

数字应急管理 (CM) 对兴奋剂使用有希望,但实施面临挑战. 这项研究发现,内部组织因素随着时间的推移成为障碍,而患者参与问题则改变了对接受者和干预因素的看法.

关键词:
应急管理的管理.数字应急管理的管理.实施的决定因素混合方法混合方法.定性分析是一种定性分析.使用物质使用物质.

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科学领域:

  • 成治疗研究研究成治疗研究
  • 数字健康实施科学科学
  • 医疗保健组织行为

背景情况:

  • 应急管理 (CM) 对兴奋剂使用障碍非常有效,但由于实施困难,往往未得到充分利用.
  • 数字CM平台为实施障碍提供了潜在的解决方案,但影响其持续交付的因素需要进一步调查.
  • 了解实施决定因素的纵向变化对于优化阿片类药物治疗计划 (OTP) 中数字CM平台的采用至关重要.

研究的目的:

  • 纵向测量影响OTP服务于兴奋剂使用者的数字CM平台采用的实施决定因素的变化.
  • 评估外部环境,内部环境,干预因素和接收者因素在6个月的实施期内如何演变.
  • 确定影响在现实临床环境中持续提供数字CM的关键障碍和促进因素.

主要方法:

  • 一项纵向研究,涉及罗德岛的五个OTP实施数字CM平台.
  • 利用影响成功实施和维持因素清单 (IFASIS) 工具,评估了27项在基线和6个月的影响和重要性等级.
  • 采用混合方法,将OTP工作人员的定量评级与转录的面试理由的定性分析相结合.

主要成果:

  • 在6个月期间,内部组织因素,包括领导承诺和政策,越来越多地被视为障碍.
  • 尽管员工流动,但员工能力仍然是一个稳定的促进者,而接收者和干预因素从被认为的促进者转变为中立或障碍的感知.
  • 在患者转诊和参与方面出现的意想不到的挑战对实施决定性评级的观察到的转变做出了重大贡献.

结论:

  • 数字CM平台的实施决定因素是动态和复杂的,需要持续监控.
  • 在实施数字化市场营销过程中,受理者和干预因素需要特别注意,因为最初的看法可能不反映长期现实.
  • 办公室医疗服务人员需要在为数字CM制定现实的期望方面得到支持,这些期望涉及到数字CM的患者识别和参与过程.