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Updated: Jan 15, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

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在ATeam ATP生物传感器中的R103和R115亲和性突变物.

Autumn Cholger1, Jason M Conley1, Stephen A Valentino1

  • 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Sensors (Basel, Switzerland)
|October 16, 2025
PubMed
概括

研究人员开发了具有不同亲和力的新型腺三酸盐 (ATP) 传感器,以测量其广泛的度范围. 这些工具有助于研究不同生理条件下的细胞能量和信号.

关键词:
这是一个ATP生物传感器.费特·弗雷特 (FRET FRET) 是一家在美国的船只.亲缘关系突变的突变者

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Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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