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单细胞和空间转录组学集成:瘤微环境和细胞通信的新前沿

Wenxin Shi1,2,3, Zhiqiang Zhang1,2, Xiaotong Xu1,2

  • 1Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Frontiers in immunology
|October 20, 2025
PubMed
概括

单细胞RNA测序 (scRNA-seq) 和空间转录组学 (ST) 共同揭示了癌症的复杂性. 整合这些技术可以提高对瘤微环境的理解,用于精确瘤学.

关键词:
癌症异质性的异质性细胞间通信是细胞间的通信.一个单细胞RNA测序.空间转录学 空间转录学瘤微环境是一个微环境.

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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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