相关实验视频

Updated: May 13, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

由ClusPro团队在CASP16中建模蛋白-蛋白和蛋白-连接体相互作用

Ryota Ashizawa1,2,3,4, Sergei Kotelnikov1,2,4, Omeir Khan5

  • 1Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, USA.

Proteins
|October 20, 2025
PubMed
概括

混合计算方法结合基于物理的采样和人工智能改进,显著提高了蛋白质复杂结构预测的准确性. 这种方法增强了蛋白质 - 蛋白质和蛋白质 - 连接体对接,在具有挑战性的情况下单独优于人工智能.

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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...