Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

562
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
562
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

870
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
870
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

804
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
804
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

294
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
294
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

377
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
377

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

From Bench to Bedside: Implications and Interventions for Endotoxin Exposure in Lipopolysaccharide-Induced Apoptosis and Eryptosis.

Blood purification·2026
Same author

Dual-Caspase-Mediated Apoptosis Underlies Peritoneal Cell-Free DNA Release After PD-Related Peritonitis.

Genes·2026
Same author

Eryptosis in Acute Patients: A Hypothesis on Its Potential Clinical Impact and Current Gaps in Evidence.

Current issues in molecular biology·2026
Same author

A Tale of Two Syndromes: The Temptation of Expanded Inclusivity in Cardiorenal Medicine.

Kidney360·2026
Same author

The Role of Online Hemodiafiltration in Contemporary Kidney Care.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Validation of Hemoglobin and Hematocrit Measurements from a Dialysis Machine Sensor Compared to Laboratory Analysis.

Journal of clinical medicine·2025

相关实验视频

Updated: Jan 13, 2026

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.8K

非蛋白质编码RNA和急性损伤:从致病源到潜在生物标志物的新进展

Grazia Maria Virzì1,2, Anna Clementi2,3, Monica Zanella1,2

  • 1Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy.

Genes
|October 29, 2025
PubMed
概括
此摘要是机器生成的。

微RNAs作为急性损伤 (AKI) 的早期生物标志物显示出希望,比传统标志物更早地检测出这种情况. 进一步的研究可能会导致AKI的新诊断工具和治疗方法.

关键词:
艾基 (AKI) 是一个人.这是一个微型RNA.微小的微小的微小的微小的微小的微小的微小不为蛋白质编码的RNA

更多相关视频

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

257
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.4K

相关实验视频

Last Updated: Jan 13, 2026

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.8K
Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

257
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.4K

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

  • 急性损伤 (AKI) 是一种具有高死亡率的严重疾病.
  • 随着当前的生物标志物,对AKI的早期诊断具有挑战性.
  • 小型非编码RNA,特别是微RNA (miRNA),正在成为潜在的诊断和治疗药物.

研究的目的:

  • 审查最近关于非编码RNAs,特别是miRNAs在AKI中的作用的发现.
  • 突出miRNAs作为AKI早期诊断生物标志物的潜力.
  • 探索miRNAs在AKI管理中的治疗应用.

主要方法:

  • 这是一篇叙事性综述,综合了现有研究.
  • 专注于在急性损伤的背景下研究微RNA的研究.
  • 检查生物流体中miRNA稳定性和诊断准确性的证据.

主要成果:

  • 特定的miRNAs (例如,miR-21,miR-30,miR-494,miR-29) 可以比血清肌素更早检测AKI.
  • miRNAs在等离子体和尿液等生物流体中稳定,使它们成为可访问的生物标志物.
  • 这些miRNAs调节基因表达,并与AKI病变发生有关.

结论:

  • 微RNA具有显著的潜力,作为早期AKI检测的敏感生物标志物.
  • miRNAs可能为AKI治疗提供新的治疗点.
  • 需要进一步的临床验证才能将这些发现转化为患者护理.