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相关概念视频

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
12.2K

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相关实验视频

Updated: Jan 12, 2026

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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后COVID-19嗅觉功能障碍中的基因表达和灰色物质体积变化:一项转录基因神经成像研究

Jixin Luan1,2, Tianyang Li2,3, Xiaolin Zhou4

  • 1Department of Radiology, China-Japan Friendship Hospital, Beijing, China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|November 2, 2025
PubMed
概括
此摘要是机器生成的。

后COVID-19嗅觉功能障碍 (PCOD) 与大脑变化有关. 脑内皮层灰质体积增加与嗅觉丧失相关,涉及特定基因表达和GABAergic神经元.

关键词:
在 COVID-19 疫情中,细胞解码的细胞解码基因转录 基因转录灰色物质体积,灰色物质体积.嗅觉功能障碍 嗅觉功能障碍

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科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • 后COVID-19嗅觉功能障碍 (PCOD) 是SARS-CoV-2感染的常见后果.
  • 在PCOD患者中观察到结构性大脑变化,但分子机制尚不清楚.

研究的目的:

  • 调查灰质体积 (GMV) 变化和PCOD患者的基因表达模式之间的关系.
  • 确定特定的生物学途径和细胞类型,涉及PCOD的病理生理学.

主要方法:

  • 36名PCOD患者和40名健康对照人接受了嗅觉心理物理测试 (嗅探棒) 和视觉模拟尺度 (VAS) 评估.
  • 在34个大脑区域分析了灰质体积 (GMV).
  • 使用了斯皮尔曼相关性,部分最小平方回归 (PLS) 和基因组丰富分析.

主要成果:

  • 经COD患者表现出脑内皮层的GMV增加,与嗅觉功能的评分 (VAS和Sniffin' Sticks) 有积极的相关性.
  • PLS分析显示,区域转基因病毒变化与特定基因表达模式之间存在显著的关联.
  • 丰富分析确定了"无机离子跨膜运输"和"蛋白质运输调节"作为关键的生物过程,在GABAergic神经元中具有高基因表达.

结论:

  • 在PCOD中改变的大脑结构与特定的基因表达特征有机械联系.
  • 这些发现强调了无机离子和蛋白质运输通路以及GABAergic神经元在PCOD病理生理学中的作用.
  • 这项研究为COVID-19后嗅觉功能障碍的分子基础提供了新的见解.